Balsalazide disodium

Names

[ Name ]:
Balsalazide disodium

[Synonym ]:
Balsalazide Disodium Salt Dihydrate
Balsalzide Disodium Hydrate
5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic Acid Disodium Salt Dihydrate
sodium, μ-[5-[(E)-2-[4-[[[2-(carboxy-κO)ethyl]amino]carbonyl]phenyl]diazenyl]-2-hydroxybenzoato(2-)-κO]-, hydrate (1:2)
Balsalazide disodium
Sodium 5-[(E)-{4-[(2-carboxylatoethyl)carbamoyl]phenyl}diazenyl]-2-hydroxybenzoate hydrate (2:1:2)
Benzoic acid, 5-[(E)-2-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]diazenyl]-2-hydroxy-, sodium salt, hydrate (1:2:2)
Balsalazide (sodium hydrate)

Biological Activity

[Description]:

Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[Target]

STAT3

IL-6

[In Vivo]

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].

[References]

[1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61.

[2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₇N₃Na₂O₈

[ Molecular Weight ]:
437.312

[ Exact Mass ]:
437.081116

[ PSA ]:
172.77000

[ LogP ]:
0.30320

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
UN 2222 3 / PGIII

[ HS Code ]:
2853009090

Customs

[ HS Code ]: 2853009090