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Ledipasvir diacetone

Names

[ CAS No. ]:
1502655-48-2

[ Name ]:
Ledipasvir diacetone

[Synonym ]:
Methyl N-[(2S)-1-[(6S)-6-[5-[9,9-Difluoro-7-[2-[(1S,2S,4R)-3-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-3-azabicyclo[2.2.1]heptan-2-yl]-3H-benzimidazol-5-yl]fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl]carbamate diacetone
GS-5885 diacetone
methyl ((S)-1-((S)-6-(5-(9,9-difluoro-7-(2-((1R,3S,4S)-2-((methoxycarbonyl)-L-valyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-6-yl)-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate compound with propan-2-one (1:2)
Ledipasvir (diacetone)

Biological Activity

[Description]:

Ledipasvir diacetone is the active pharmaceutical ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease
Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection

[In Vitro]

Ledipasvir diacetone is considered the active pharmaceutical ingredient, which is converted to Ledipasvir spray-dried dispersion, an amorphous free base.

[Related Small Molecules]

Asunaprevir | Sofosbuvir | Simeprevir | Ledipasvir | paritaprevir | Artemisinin | Elbasvir | NIM811 | MK-5172 | velpatasvir | Ombitasvir | Danoprevir (ITMN-191) | Glecaprevir | Celgosivir (hydrochloride) | Alisporivir

Chemical & Physical Properties

[ Molecular Formula ]:
C55H66F2N8O8

[ Molecular Weight ]:
1005.16000

[ Exact Mass ]:
1004.50000

[ PSA ]:
208.78000

[ LogP ]:
10.45550

[ Storage condition ]:
2-8℃

Related Compounds