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Clivatuzumab tetraxetan

Names

[ CAS No. ]:
1462876-11-4

[ Name ]:
Clivatuzumab tetraxetan

Biological Activity

[Description]:

Clivatuzumab tetraxetan (IMMU107) is a humanized anti-MUC1 monoclonal antibody. Clivatuzumab tetraxetan shows anti-tumor activity. Clivatuzumab tetraxetan has the potential for the research of metastatic pancreatic cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vivo]

Clivatuzumab tetraxetan (50, 100 µg; i.v.; once 以剂量依赖性方式减小肿瘤体积并增加小鼠的中位生存期[2]。 Animal Model: Nude mice (Capan-1 tumors)[2] Dosage: 50, 100 µg Administration: I.v.; once Result: Significantly decreased tumor volume in a dose-dependent manaer and increased the median survival to 13 weeks.

[References]

[1]. Shimizu M, et al. Thrombin-induced platelet aggregation -effect of dabigatran using automated platelet aggregometry. Platelets. 2020;31(3):360-364.  

[2]. Sharkey RM, et al. Combination radioimmunotherapy and chemoimmunotherapy involving different or the same targets improves therapy of human pancreatic carcinoma xenograft models. Mol Cancer Ther. 2011 Jun;10(6):1072-81.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds