6-CHLORO-9-[3-N-(2-CHLOROETHYL)ETHYLAMINO]PROPYLAMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE
Names
[ CAS No. ]:
146-59-8
[ Name ]:
6-CHLORO-9-[3-N-(2-CHLOROETHYL)ETHYLAMINO]PROPYLAMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE
[Synonym ]:
MFCD00012658
acridine mutagen ICR 170 dihydrochloride
6-CHLORO-9-[3-N-(2-CHLOROETHYL)ETHYLAMINO]PROPYLAMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE
ICR 170 ACRIDINE MUTAGEN*DIHYDROCHLORIDE
9-(3-(ethyl(2-chloroethyl)amino)propylamino)-6-chloro-2-methoxyacridinedihyd
6-chloro-9-(3-n-(2-chloroethyl)ethylamino]propylamino-2-methoxyacridine.2
icr170
EINECS 205-675-7
ACRIDINEICR170
6-chloro-9-(3-(n-(2-chloroethyl)-n-ethylamino)propylamino)-2-methoxy-acridin
acridinemustard
Chemical & Physical Properties
[ Boiling Point ]:
546.9ºC at 760mmHg
[ Melting Point ]:
231-232ºC
[ Molecular Formula ]:
C21H27Cl4N3O
[ Molecular Weight ]:
479.27100
[ Flash Point ]:
284.5ºC
[ Exact Mass ]:
477.09100
[ PSA ]:
37.39000
[ LogP ]:
7.08970
[ Vapour Pressure ]:
5.17E-12mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AR7680000
- CHEMICAL NAME :
- Acridine, 6-chloro-9-(3-(N-(2-chloroethyl)-N-ethylamino)propyla mino)-2-methoxy-, dihydrochloride
- CAS REGISTRY NUMBER :
- 146-59-8
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 47
- MOLECULAR FORMULA :
- C21-H25-Cl2-N3-O.2Cl-H
- MOLECULAR WEIGHT :
- 479.31
- WISWESSER LINE NOTATION :
- T C666 BNJ EG IM3N2&2G LO1 &GH &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD20 - Lethal Dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4800 ug/kg/28D-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 4 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 1 umol/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 8,113,1974
Safety Information
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
68-40-23/24/25
[ Safety Phrases ]:
S22;S45;S36/S37/S39
[ RIDADR ]:
UN 2811
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)