KDM2/7-IN-1

Names

[ Name ]:
KDM2/7-IN-1

[Synonym ]:
3-(9-cyclopropyl-N-hydroxynonanamido)propanoic acid
3-(N-hydroxy-9-cyclopropylnonanamido)propanoic acid

Biological Activity

[Description]:

KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Demethylase

[References]

[1]. Suzuki T, et al. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem. 2013 Sep 26;56(18):7222-31.

Chemical & Physical Properties

[ Melting Point ]:
87 °C

[ Molecular Formula ]:
C₁₅H₂₇NO₄

[ Molecular Weight ]:
285.37900

[ Exact Mass ]:
285.19400

[ PSA ]:
77.84000

[ LogP ]:
3.20970

Related Compounds

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