mGluR2 antagonist 1
Names
[ CAS No. ]:
1432728-49-8
[ Name ]:
mGluR2 antagonist 1
Biological Activity
[Description]:
mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1].
[Related Catalog]:
[Target]
mGluR2:9 nM (IC50)
[In Vivo]
In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C21H16FN3O3
[ Molecular Weight ]:
377.37