ACHN-975

Names

[ Name ]:
ACHN-975

[Synonym ]:
MFCD29991590

Biological Activity

[Description]:

ACHN-975 is a selective LpxC inhibitor, exhibiting a subnanomolar LpxC inhibitory activity and low MIC values (≤1 μg/mL) against a wide range of Gram-negative bacteria. LpxC is highly conserved in Gram-negative bacteria and catalyzes the first committed step of lipid A biosynthesis[1]. LpxC is the bacterial enzyme Zinc-dependent metalloamidase UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

LpxC[1]

[In Vitro]

ACHN-975 is against Enterobacteriaceae spp with an IC50 of 0.02 nM[1]. ACHN-975 is against Enterobacteriaceae spp, Pa, and Ab with MIC90 values of 1, 0.5, and >64 μg/mL, respectively[1].

[References]

[1]. Kalinin DV, et al. Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design. Curr Top Med Chem. 2016;16(21):2379-430.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₃N₃O₄

[ Molecular Weight ]:
369.41

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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