Fmoc-Lys-OH hydrochloride

Names

[ Name ]:
Fmoc-Lys-OH hydrochloride

[Synonym ]:
Nalpha-Fmoc-L-lysinehydrochloride
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid hydrochloride
Fmoc-Lys-OH hydrochloride
Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine Hydrochloride
Fmoc-Lys-OH.HCl
Fmoc-L-lysine HCl
N2-Fmoc-L-lysine HCl
MFCD00190889
Fmoc-L-lysine hydrochloride
Nalpha-Fmoc-L-Lysine Hydrochloride
L-Lysine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrochloride (1:1)
Nalpha-[(9H-Fluoren-9-ylMethoxy)carbonyl]-L-lysine Hydrochloride
Fmoc-Lys-OH inverted exclamation mark currencyHCl
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine hydrochloride (1:1)
Nα-Fmoc-L-lysine Hydrochloride

Biological Activity

[Description]:

Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Boiling Point ]:
607.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₅ClN₂O₄

[ Molecular Weight ]:
404.887

[ Flash Point ]:
321.3ºC

[ Exact Mass ]:
404.150299

[ PSA ]:
101.65000

[ LogP ]:
5.00050

[ Vapour Pressure ]:
1.29E-15mmHg at 25°C

[ Index of Refraction ]:
-11.0 ° (C=1, DMF)

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%