(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)

Names

[ Name ]:
(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)

[Synonym ]:
L-Leucine, N-[(2S)-2,6-diaminohexyl]-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-
N-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine
m.w. 746.96 c38h66n8o7

Biological Activity

[Description]:

JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.5 nM in binding to mouse brain membranes and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor

Research Areas >> Neurological Disease

[References]

[1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198.

[2]. Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1044.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₈H₆₆N₈O₇

[ Molecular Weight ]:
746.980

[ Flash Point ]:
585.3±34.3 °C

[ Exact Mass ]:
746.505432

[ PSA ]:
255.23000

[ LogP ]:
2.02

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.556

Related Compounds

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