[Lys8, Lys9]-Neurotensin (8-13)

Names

[ Name ]:
[Lys8, Lys9]-Neurotensin (8-13)

[Synonym ]:
[lys8,9]-neurotensin (8-13)
lys-lys-pro-tyr-ile-leu
h-lys-lys-pro-tyr-ile-leu-oh
kkpyil
(lys8,lys9)-neurotensin (8-13)

Biological Activity

[Description]:

[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor

Research Areas >> Neurological Disease

[References]

[1]. Emilie Eiselt, et al. Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS Chem Neurosci. 2019 Nov 20;10(11):4535-4544.

Chemical & Physical Properties

[ Density]:
1.203 g/cm3

[ Boiling Point ]:
1109.7ºC at 760 mmHg

[ Molecular Formula ]:
C₃₈H₆₄N₈O₈

[ Molecular Weight ]:
760.96400

[ Flash Point ]:
624.9ºC

[ Exact Mass ]:
760.48500

[ PSA ]:
272.30000

[ LogP ]:
4.22940

[ Storage condition ]:
-20°C

[Lys8, Lys9]-Neurotensin (8-13)

Names

Biological Activity

Chemical & Physical Properties

Related Compounds