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SR 10067

Names

[ CAS No. ]:
1380548-02-6

[ Name ]:
SR 10067

Biological Activity

[Description]:

SR10067 is a potent, selective and brain penetrant Rev-Erbα/β agonist, with IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively. SR10067 has anxiolytic activity[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

IC50: 160 nM (Rev-Erbβ), 170 nM (Rev-Erbα)[1].


[References]

[1]. Banerjee S, et al. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat Commun. 2014 Dec 23;5:5759. doi: 10.1038/ncomms6759.

[2]. Thevis M, et al. Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun Mass Spectrom. 2016 Mar 15;30(5):635-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H31NO3

[ Molecular Weight ]:
465.58

[ Storage condition ]:
-20°C

Related Compounds