CCK-A receptor inhibitor 1

CCK-A receptor inhibitor 1 is a cholecystokinin A (CCK-A) receptor inhibitor with a binging IC50 of 340 nM.

Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor

Research Areas >> Metabolic Disease

IC50: 340 nM (CCK-A receptor)[1]

CCK-A receptor inhibitor 1 (Compound 7c) is a naphthyl sulfone derivative, which is synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inhibitory activities are found in CCK-A receptor inhibitor 1 having very hydrophobic sidechains[1].

[1]. Ajisawa Y, et al. [Studies on the synthesis of cholecystokinin A receptor antagonists. III. Synthesis and cholecystokinin A receptor inhibitory activities of naphthyl sulfone derivatives]. Yakugaku Zasshi. 1996 Aug;116(8):647-56.

Caerulein ammonium salt | Gastrin I (human) | Nastorazepide | Loxiglumide | Proglumide | Sograzepide | Tarazepide | CCK-B Receptor Antagonist 1 | 1H-Indole-2-carboxamide, N-[(3R)-1-(2-fluorophenyl)-3,4,6,7-tetrahydro-4-oxopyrrolo[3,2,1-jk][1,4]benzodiazepin-3-yl]- | Gastrin/CCK antagonist 1 | GI 181771 | Mini Gastrin I, human | SR 146131