SKA-111

A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM; displays 123-fold selectivity over KCa2.3 (EC50=13.7 uM), and 200- to 400-fold selective over representative KV, NaV, as well as CaV1.2 channels; not only lowers blood pressure but also drastically reduces heart rate, presumably through cardiac and neuronal KCa2 activation in mice.

References 1. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57. 2. Oliván-Viguera A, et al. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. View Related Products by Target Potassium Channel