DB2115

Names

[ Name ]:
DB2115

Biological Activity

[Description]:

DB2115 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM; decrease cell growth (IC50=3.4 uM) and the clonogenic capacity of AML cells and leads to increased apoptosis, while showing little effect on normal hematopoietic cells; decreases tumor burden and increases survival in murine and human AML transplantation models.

[References]

References 1. Antony-Debré I, et al. J Clin Invest. 2017 Oct 30. pii: 92504. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₀N₈O₂

[ Molecular Weight ]:
558.646

Related Compounds

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