BNC210

Names

[ Name ]:
BNC210

[Synonym ]:
REF DUPL: H-Ile-Trp-OH
L-ISOLEUCYL-L-TRYPTOPHAN
BNC210

Biological Activity

[Description]:

BNC210 (H-Ile-Trp-OH; IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[References]

[1]. Toby Wise, et al. Cholinergic Modulation of Disorder-Relevant Neural Circuits in Generalised Anxiety Disorder (GAD) by BNC210, a negative allosteric modulator of α7 nAChR.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₃N₃O₃

[ Molecular Weight ]:
317.38300

[ Exact Mass ]:
317.17400

[ PSA ]:
108.21000

[ LogP ]:
2.74440

Related Compounds

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