LIN28 inhibitor LI71

Names

[ Name ]:
LIN28 inhibitor LI71

Biological Activity

[Description]:

LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> MicroRNA

Research Areas >> Others

[Target]

IC50: 7 uM (LIN28)[1]

[References]

[1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₁NO₃

[ Molecular Weight ]:
335.40

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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