AQ-101

Names

[ Name ]:
AQ-101

[Synonym ]:
2-Chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenyl)acetamide
Acetamide, 2-chloro-N-(9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenyl)-

Biological Activity

[Description]:

AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53; induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo; inhibits development of ALL in nude or SCID mice with a human ALL xenograft.

[References]

References 1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
639.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₀ClNO₅

[ Molecular Weight ]:
331.707

[ Flash Point ]:
340.7±31.5 °C

[ Exact Mass ]:
331.024750

[ LogP ]:
4.36

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.749

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.