SKI-2852

Names

[ Name ]:
SKI-2852

Biological Activity

[Description]:

A highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively; demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity; significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo.

[References]

References 1. Ryu JH, et al. J Med Chem. 2016 Nov 23;59(22):10176-10189. View Related Products by Target 11β-HSD

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₄FN₅O₄S

[ Molecular Weight ]:
543.658

Related Compounds

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