2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-N-2-PROPYNYL-, HYDROCHLORIDE

Names

[ Name ]:
2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-N-2-PROPYNYL-, HYDROCHLORIDE

[Synonym ]:
N-(2-Propyn-1-yl)-1,2,3,4-tetrahydro-2-naphthalenamine hydrochloride (1:1)
MFCD09998861
2-Naphthalenamine, 1,2,3,4-tetrahydro-N-2-propyn-1-yl-, hydrochloride (1:1)

Biological Activity

[Description]:

2-PAT, an analogue of Rasagiline and Selegiline, a reversible MAO-A inhibitor with an IC50 of 0.721 µM. 2-PAT is an inactivator of MAO-B with an IC50 of 14.6 µM. 2-PAT has the potential for Parkinson’s disease and depression research[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[Target]

MAO-A:0.721 μM (IC50)

MAO-B:14.6 μM (IC50)

[References]

[1]. Letitia Meiring, et al. The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase. Bioorg Med Chem Lett. 2022 Jul 1;67:128746.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₆ClN

[ Molecular Weight ]:
221.726

[ Exact Mass ]:
221.097122

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.