PD 132002

Names

[ Name ]:
PD 132002

[Synonym ]:
methyl <1S-(1R*,2S*,3R*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N-<N-(4-morpholinylsulfonyl)-L-phenylalanyl>-3-oxo-DL-alaninate
(1S-(1R*,2S*,3R*))-3-{[1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]amino}-N-[N-(4-morpholinosulfonyl)-L-phenylalanyl]-3-oxo-DL-alanine methyl ester
2-methoxy-6-[(4-methylphenyl)sulfonyloxymethyl]oxane-3,4,5-triol

Biological Activity

[Description]:

PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Renin

[References]

[1]. J T Repine, et al. Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate. J Med Chem. 1991 Jul;34(7):1935-43.

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Molecular Formula ]:
C₃₁H₅₀N₄O₉S

[ Molecular Weight ]:
654.81500

[ Exact Mass ]:
654.33000

[ PSA ]:
195.47000

[ LogP ]:
3.28600

[ Index of Refraction ]:
1.579

Related Compounds

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