hDHODH-IN-9

Names

[ CAS No. ]:
133676-47-8

[ Name ]:
hDHODH-IN-9

Biological Activity

[Description]:

hDHODH-IN-9 (Compound 3k) is a potent inhibitor of hDHODH with an IC50 of 0.34 μM. hDHODH-IN-9 demonstrates high cytotoxic activity against MCF-7 and A375 cells and good selectivity. hDHODH-IN-9 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

[References]

[1]. Petrović MM, et al. Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes: Synthesis, cytotoxicity, lipophilicity and molecular docking studies. Bioorg Chem. 2020;105:104373.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H21NO4

[ Molecular Weight ]:
351.40

Related Compounds