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AG 538

Names

[ CAS No. ]:
133550-18-2

[ Name ]:
AG 538

[Synonym ]:
AGS 199
(2E)-2-(3,4-Dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile
AG538
Benzenepropanenitrile, α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)-
AG 538
3,4-dihydroxy-α-(3,4-dihydroxybenzoyl)-cis-cinnamonitrile
tyrphostin AG 538

Biological Activity

[Description]:

AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IGF-1R

[References]

[1]. G Blum, et al. Substrate Competitive Inhibitors of IGF-1 Receptor Kinase. Biochemistry. 2000 Dec 26;39(51):15705-12.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
637.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H11NO5

[ Molecular Weight ]:
297.262

[ Flash Point ]:
339.3±31.5 °C

[ Exact Mass ]:
297.063721

[ PSA ]:
121.78000

[ LogP ]:
1.79

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.754

Related Compounds