Akt1&PKA-IN-1

Names

[ CAS No. ]:
1334107-58-2

[ Name ]:
Akt1&PKA-IN-1

Biological Activity

[Description]:

Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC50 values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively. Akt1&PKA-IN-1 is selective for cyclin-dependent kinase 2 (CDK2)[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA
Research Areas >> Others
Signaling Pathways >> Stem Cell/Wnt >> PKA
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

PKAa:0.03 μM (IC50)

Akt:0.11 μM (IC50)

CDK2:9.8 μM (IC50)


[References]

[1]. Ashton KS, et al. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5191-6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H17Cl2N3O

[ Molecular Weight ]:
386.27

Related Compounds

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