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TRC051384 HCl

Names

[ CAS No. ]:
1333327-56-2

[ Name ]:
TRC051384 HCl

[Synonym ]:
MFCD31539844
1-[2-(4-Morpholinyl)ethyl]-3-(4-{(2E)-3-[6-(4-morpholinyl)-2-pyridinyl]-2-propenoyl}phenyl)urea hydrochloride (1:1)
Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[(2E)-3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-, hydrochloride (1:1)

Biological Activity

[Description]:

TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). TRC051384 hydrochloride exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 hydrochloride can be used for the research of ischemic stroke[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Research Areas >> Neurological Disease

[References]

[1]. Mohanan A, et, al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60(6):991-9.

[2]. Chen T, et, al. HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma. Mol Biol Rep. 2023 Sep;50(9):7237-7244.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H32ClN5O4

[ Molecular Weight ]:
502.01

[ Exact Mass ]:
501.214294

Related Compounds