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Phostriecin

Names

[ CAS No. ]:
131774-59-9

[ Name ]:
Phostriecin

[Synonym ]:
phosphorylcholine calcium salt tetrahydrate
Ipercolin Tetrahydrate
Epafosforil Tetrahydrate
Biocalcose Tetrahydrate
Colifos Tetrahydrate
Merival Tetrahydrate
Isocolin Tetrahydrate
Pancholin Tetrahydrate
Mebophos Tetrahydrate
Fosfocolina Tetrahydrate
phostriecin
Phoscholin Tetrahydrate

Biological Activity

[Description]:

Phostriecin is an antitumor antibiotic produced by Streptomyces pulveraceus. Phostriecin is a strong inhibitor of type 2A (PP2A) and a weak inhibitor of type 1 (PP1) serine/threonine protein phosphatases with IC50s of 3.2 nM and 131 μM, respectively. Phostriecin has the potential for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[References]

[1]. Walsh AH, et al. Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 1997 Oct 27;416(3):230-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H33NaO8S

[ Molecular Weight ]:
492.55800

[ Exact Mass ]:
492.17900

[ PSA ]:
141.57000

[ LogP ]:
3.94730

Related Compounds