131774-59-9

131774-59-9 structure

Name: Phostriecin
Chemical Name: Sultriecin
CAS Number: 131774-59-9
Molecular Formula: C₂₃H₃₃NaO₈S
Molecular Weight: 492.55800
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2017-04-26 03:44:34
Modify Date: 2025-08-25 18:28:07
Phostriecin is an antitumor antibiotic produced by Streptomyces pulveraceus. Phostriecin is a strong inhibitor of type 2A (PP2A) and a weak inhibitor of type 1 (PP1) serine/threonine protein phosphatases with IC50s of 3.2 nM and 131 μM, respectively. Phostriecin has the potential for the research of cancer[1].

Name	Sultriecin
Synonyms	phosphorylcholine calcium salt tetrahydrate Ipercolin Tetrahydrate Epafosforil Tetrahydrate Biocalcose Tetrahydrate Colifos Tetrahydrate Merival Tetrahydrate Isocolin Tetrahydrate Pancholin Tetrahydrate Mebophos Tetrahydrate Fosfocolina Tetrahydrate phostriecin Phoscholin Tetrahydrate

Description	Phostriecin is an antitumor antibiotic produced by Streptomyces pulveraceus. Phostriecin is a strong inhibitor of type 2A (PP2A) and a weak inhibitor of type 1 (PP1) serine/threonine protein phosphatases with IC50s of 3.2 nM and 131 μM, respectively. Phostriecin has the potential for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Infection Research Areas >> Inflammation/Immunology
References	[1]. Walsh AH, et al. Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 1997 Oct 27;416(3):230-4.