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Lys-Nε-SPDB-DM4

Names

[ CAS No. ]:
1280215-91-9

[ Name ]:
Lys-Nε-SPDB-DM4

Biological Activity

[Description]:

Lys-Nε-SPDB-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody drug conjugate (ADC)[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Maytansinoids


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Hans K Erickson, et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res. 2006 Apr 15;66(8):4426-33.

Chemical & Physical Properties

[ Molecular Formula ]:
C48H72ClN5O13S2

[ Molecular Weight ]:
1026.69

Related Compounds