(±)-Naproxen-13C,d3

Names

[ CAS No. ]:
1261392-52-2

[ Name ]:
(±)-Naproxen-13C,d3

[Synonym ]:
2-Naphthaleneacetic acid, α-methyl-6-(methyl-13C-d3-oxy)-
2-{6-[(13C,2H3)Methyloxy]-2-naphthyl}propanoic acid

Biological Activity

[Description]:

(±)-Naproxen-13C,d3 is the deuterium and 13C labeled (±)-Naproxen[1]. (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> COX

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C1313CH11D3O3

[ Molecular Weight ]:
234.270

[ Exact Mass ]:
234.116486

[ Index of Refraction ]:
1.609

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds