Pitofenone hydrochloride

Names

[ Name ]:
Pitofenone hydrochloride

[Synonym ]:
2-[4-(2-Piperidino-aethoxy)-benzoyl]-benzoesaeure-methylester,Hydrochlorid
methyl 2-[4-(2-piperidin-1-ylethoxy)benzoyl]benzoate hydrochloride
2-[4-(2-piperidino-ethoxy)-benzoyl]-benzoic acid methyl ester,hydrochloride
pitofenone hydrochloride
methyl 2-[4-(2-piperidin-1-ylethoxy)phenyl]carbonylbenzoate hydrochloride
methyl 2-[4-(2-piperidinoethoxy)benzoyl]benzoate hydrochloride

Biological Activity

[Description]:

Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> AChE

Research Areas >> Neurological Disease

[Target]

Ki: 36 μM (AChE, bovine erythrocytes), 45 μM (AChE, electric eel)

[References]

[1]. Punekar NS, et al. Acetylcholinesterase inhibition by pitofenone: a spasmolytic compound. Biotechnol Appl Biochem. 1991 Dec;14(3):378-82.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
512ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₆ClNO₄

[ Molecular Weight ]:
403.89900

[ Flash Point ]:
263.4ºC

[ Exact Mass ]:
403.15500

[ PSA ]:
55.84000

[ LogP ]:
4.30880

[ Vapour Pressure ]:
1.35E-10mmHg at 25°C

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH6477800

CHEMICAL NAME :: Benzoic acid, o-(p-(2-piperidinoethoxy)benzoyl)-, methyl ester, hydrochloride

CAS REGISTRY NUMBER :: 1248-42-6

LAST UPDATED :: 198912

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H25-N-O4.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

Safety Information

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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