BI-69A11

Names

[ Name ]:
BI-69A11

[Synonym ]:
3-[(2E)-3-(1H-Benzimidazol-2-yl)-2-propenoyl]-6-chloro-4-phenyl-2(1H)-quinolinone
2(1H)-Quinolinone, 3-[(2E)-3-(1H-benzimidazol-2-yl)-1-oxo-2-propen-1-yl]-6-chloro-4-phenyl-
MFCD00186600
(2E)-3-(1H-benzimidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one

Biological Activity

[Description]:

A potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1; displays no activity for other protein kinases including Abl1, p38α, JNK, and PI3K (IC50>100 uM); causes partial inhibition of AKT phosphorylation on S473 on melanoma cells at 3 uM; reduces AKT protein expression and AKT association with HSP-90; caused effective regression of melanoma tumor xenografts.

[References]

References 1. Gaitonde S, et al. Pigment Cell Melanoma Res. 2009 Apr;22(2):187-95. 2. Feng Y, et al. Pigment Cell Melanoma Res. 2013 Jan;26(1):136-42. 3. Pal I, et al. Br J Cancer. 2014 Jul 8;111(1):101-11. View Related Products by Target Akt

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₅H₁₆ClN₃O₂

[ Molecular Weight ]:
425.866

[ Exact Mass ]:
425.093109

[ LogP ]:
5.42

[ Index of Refraction ]:
1.742

Related Compounds

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