Crotonaldehyde
Names
[ CAS No. ]:
123-73-9
[ Name ]:
Crotonaldehyde
[Synonym ]:
2-BUTENAL
Topanel
CH3CH=CHCHO
Crotonal
2-BUTEN-1-AL
Bu-2-tenal
Topanel CA
t-2-Butenal
MFCD00007003
(E)-2-Butenal
BUTENAL
Crotonaldehyde
but-2-en-1-al
EINECS 204-647-1
Chemical & Physical Properties
[ Density]:
0.8±0.1 g/cm3
[ Boiling Point ]:
104.0±0.0 °C at 760 mmHg
[ Melting Point ]:
−76 °C(lit.)
[ Molecular Formula ]:
C4H6O
[ Molecular Weight ]:
70.090
[ Flash Point ]:
4.6±4.3 °C
[ Exact Mass ]:
70.041862
[ PSA ]:
17.07000
[ LogP ]:
0.51
[ Vapour density ]:
2.41 (vs air)
[ Vapour Pressure ]:
31.4±0.1 mmHg at 25°C
[ Index of Refraction ]:
1.402
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
150 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GP9625000
- CHEMICAL NAME :
- Crotonaldehyde, (E)-
- CAS REGISTRY NUMBER :
- 123-73-9
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 30
- MOLECULAR FORMULA :
- C4-H6-O
- MOLECULAR WEIGHT :
- 70.10
- WISWESSER LINE NOTATION :
- VH1U2 -T
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Human
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 12 mg/m3/10M
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4000 mg/m3/30M
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1510 mg/m3/2H
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 568 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 380 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1331 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Sperm Morphology
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 283,131,1992 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 2 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 2 ppm (6 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 2 ppm (6 mg/m3) JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (6 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (6 mg/m3);STEL 6 ppm (18 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CROTONALDEHYDE-air:10H TWA 2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311-H315-H318-H330-H335-H341-H373-H400
[ Precautionary Statements ]:
P201-P210-P260-P280-P304 + P340 + P310-P370 + P378
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable;T+:Verytoxic;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R11;R24/25;R26;R37/38;R41;R48/22;R50;R68
[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S61-S28A
[ RIDADR ]:
UN 1143 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
GP9625000
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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