2-Vinyloxirane
Names
[ CAS No. ]:
930-22-3
[ Name ]:
2-Vinyloxirane
[Synonym ]:
2-Vinyloxirane
3,4-EPOXY-1-BUTENE
EINECS 213-210-4
Oxirane, 2-ethenyl-
2-ethenyloxirane
MFCD00005149
UNII:478ERR5NKR
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
70.0±9.0 °C at 760 mmHg
[ Melting Point ]:
-135ºC
[ Molecular Formula ]:
C4H6O
[ Molecular Weight ]:
70.090
[ Flash Point ]:
-50.0±0.0 °C
[ Exact Mass ]:
70.041862
[ PSA ]:
12.53000
[ LogP ]:
-0.03
[ Vapour Pressure ]:
142.6±0.1 mmHg at 25°C
[ Index of Refraction ]:
1.578
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EM7350000
- CHEMICAL NAME :
- 1-Butene, 3,4-epoxy-
- CAS REGISTRY NUMBER :
- 930-22-3
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 24
- MOLECULAR FORMULA :
- C4-H6-O
- MOLECULAR WEIGHT :
- 70.10
- WISWESSER LINE NOTATION :
- T3OTJ B1U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 168 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 492 gm/kg/41W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Mutation in mammalian somatic cells
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 625 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H302-H319
[ Precautionary Statements ]:
P210-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Highlyflammable;Xn:Harmful;
[ Risk Phrases ]:
R11;R40
[ Safety Phrases ]:
S16-S36/37-S45
[ RIDADR ]:
UN 1993 3/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
EM7350000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
[ HS Code ]:
2910900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2910900090
[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
Articles
Toxicol. Appl. Pharmacol. 281(3) , 276-84, (2014)
1,3-Butadiene (BD) is a rodent and human carcinogen. In the cancer tests, mice have been much more susceptible than rats with regard to BD-induced carcinogenicity. The species-differences are dependen...
Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells.Chem. Biol. Interact. 166(1-3) , 207-18, (2007)
The carcinogenicity of 1,3-butadiene (BD) is related to its bioactivation to several DNA-reactive metabolites; accumulating evidence suggests that the stereochemistry of these BD intermediates may pla...
Dose responses for DNA adduct formation in tissues of rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-[(14)C]-butadiene.Chem. Biol. Interact. 147(2) , 195-211, (2004)
Male Sprague-Dawley rats and B6C3F1 mice were exposed to either a single 6h or a multiple (5) daily (6h) nose-only dose of 1,3-[2,3-(14)C]-butadiene at exposure concentrations of nominally 1, 5 or 20 ...