2′-Deoxy-N-(2-furanylmethyl)guanosine

Names

[ Name ]:
2′-Deoxy-N-(2-furanylmethyl)guanosine

[Synonym ]:
2'-Deoxy-N-(2-furylmethyl)guanosine
Guanosine, 2'-deoxy-N-(2-furanylmethyl)-

Biological Activity

[Description]:

2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Molecular Formula ]:
C₁₅H₁₇N₅O₅

[ Molecular Weight ]:
347.33

[ Exact Mass ]:
347.122955

[ LogP ]:
-1.79

[ Index of Refraction ]:
1.798

Related Compounds

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