LCL521

Names

[ CAS No. ]:
1226851-11-1

[ Name ]:
LCL521

Biological Activity

[Description]:

LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

ACDase, ASMase[1]

[In Vitro]

LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10 µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells[1].

[References]

[1]. Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₅₂N₄O₇

[ Molecular Weight ]:
592.77

[ Storage condition ]:
2-8℃

Related Compounds

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