Emtricitabine-13C,15N2

Names

[ Name ]:
Emtricitabine-13C,15N2

[Synonym ]:
4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone-13C,15N2
BW 1592-13C,15N2
BW 524W91-13C,15N2
Coviracil-13C,15N2
2(1H)-Pyrimidinone-2-13C-1,3-15N2, 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
(-)-2'-Deoxy-5-fluoro-3'-thiacytidine-13C,15N2
4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-(2-13C,15N2)pyrimidinone
(-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine-13C,15N2

Biological Activity

[Description]:

Emtricitabine-13C,15N2 (BW1592-13C,15N2) is a 13C- and 15N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.

[2]. Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.

[3]. Faltz M, et al. Effect of the Anti-retroviral Drugs Efavirenz, Tenofovir and Emtricitabine on Endothelial Cell Function: Role of PARP. Cardiovasc Toxicol. 2017 Jan 3. [Epub ahead of print]

[4]. Szczech GM, Wang LH, Walsh JP, Reproductive toxicology profile of emtricitabine in mice and rabbits. Reprod Toxicol. 2003 Jan-Feb;17(1):95-108.

[5]. Saag MS, et al. Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus. Clin Infect Dis. 2006 Jan 1;42(1):126-31.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Melting Point ]:
>145° C (dec.)

[ Molecular Formula ]:
C₇₁₃CH₁₀FN₁₅N₂O₃S

[ Molecular Weight ]:
250.23

[ Exact Mass ]:
250.040115

[ Index of Refraction ]:
1.731

[ Water Solubility ]:
Soluble in Ether and Methanol