1217820-69-3

1217820-69-3 structure

Name: Emtricitabine-13C,15N2
Chemical Name: (-)-Emtricitabine-¹³C,¹⁵N2
CAS Number: 1217820-69-3
Molecular Formula: C₇₁₃CH₁₀FN₁₅N₂O₃S
Molecular Weight: 250.23
Catalog: Research Areas Infection
Create Date: 2022-04-13 15:00:52
Modify Date: 2023-01-17 17:08:25
Emtricitabine-13C,15N2 (BW1592-13C,15N2) is a 13C- and 15N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

Name	(-)-Emtricitabine-¹³C,¹⁵N2
Synonyms	4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone-13C,15N2 BW 1592-13C,15N2 BW 524W91-13C,15N2 Coviracil-13C,15N2 2(1H)-Pyrimidinone-2-13C-1,3-15N2, 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]- (-)-2'-Deoxy-5-fluoro-3'-thiacytidine-13C,15N2 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-(2-13C,15N2)pyrimidinone (-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine-13C,15N2

Description	Emtricitabine-13C,15N2 (BW1592-13C,15N2) is a 13C- and 15N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
Related Catalog	Research Areas >> Infection
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [2]. Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692. [3]. Faltz M, et al. Effect of the Anti-retroviral Drugs Efavirenz, Tenofovir and Emtricitabine on Endothelial Cell Function: Role of PARP. Cardiovasc Toxicol. 2017 Jan 3. [Epub ahead of print] [4]. Szczech GM, Wang LH, Walsh JP, Reproductive toxicology profile of emtricitabine in mice and rabbits. Reprod Toxicol. 2003 Jan-Feb;17(1):95-108. [5]. Saag MS, et al. Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus. Clin Infect Dis. 2006 Jan 1;42(1):126-31.

Density	1.8±0.1 g/cm3
Melting Point	>145° C (dec.)
Molecular Formula	C₇₁₃CH₁₀FN₁₅N₂O₃S
Molecular Weight	250.23
Exact Mass	250.040115
Index of Refraction	1.731
Water Solubility	Soluble in Ether and Methanol