Mirtazapine D3

Names

[ Name ]:
Mirtazapine D3

Biological Activity

[Description]:

Mirtazapine D3 (Org3770 D3; 6-Azamianserin D3) is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT2 Receptor

5-HT3 Receptor

[In Vivo]

Mirtazapine (intraperitoneal injection; 10–50 mg/Kg; 14 days) treatment normalizes heart rate, breath rate, anxiety levels and eliminates the hopping behavior observed in MeCP2-null mice, leading to improved phenotypic score[2]. Animal Model: MeCP2 null mice[2] Dosage: 10-50 mg/Kg Administration: Intraperitoneal injection; 10-50 mg/Kg; 14 days Result: Restored the thickness of MeCP2-null mice somatosensory cortex, especially of layers II-III and VI.

[References]

[1]. Anttila, S.A. and E.V. Leinonen, A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 2001. 7(3): p. 249-64.

[2]. Kooyman AR, et al. Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells.Neuropharmacology. 1994 Mar-Apr;33(3-4):501-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₆D₃N₃

[ Molecular Weight ]:
268.37100

[ Exact Mass ]:
268.17700

[ PSA ]:
19.37000

[ LogP ]:
2.48180

Related Compounds

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