Sorafenib-d4

Names

[ CAS No. ]:
1207560-07-3

[ Name ]:
Sorafenib-d4

Biological Activity

[Description]:

Sorafenib D4 (Bay 43-9006 D4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H12D4ClF3N4O3

[ Molecular Weight ]:
468.85

Related Compounds