acetaminophen glucuronide sodium salt

Names

[ CAS No. ]:
120595-80-4

[ Name ]:
acetaminophen glucuronide sodium salt

[Synonym ]:
MFCD00153898
ACETAMINOPHEN GLUCURONIDE SODIUM SALT
Acetaminophen glucuronide,Paracetamol glucuronide
Acetaminophen glucuronide Paracetamol glucuronide

Biological Activity

[Description]:

Acetaminophen glucuronide is a safe and effectiveantipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liverand kidney [1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. MazaleuskayaLL, et al. PharmGKB summary: pathways of acetaminophen metabolism at thetherapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.

Chemical & Physical Properties

[ Melting Point ]:
232-233ºC (dec)

[ Molecular Formula ]:
C₁₄H₁₆NNaO₈

[ Molecular Weight ]:
349.27

[ Exact Mass ]:
349.07700

[ PSA ]:
148.38000

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition.

Drug Metab. Dispos. 43(1) , 147-53, (2014)

This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake...

Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater.

J. Pharm. Biomed. Anal. 106 , 61-70, (2015)

An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic gro...

The effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite: paracetamol glucuronide.

Eur. J. Drug Metab. Pharmacokinet. 40 , 163-70, (2015)

The study aimed to examine the effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite, paracetamol glucuronide. Both drugs share metabolic pathways in the liver...