ST-1006
Names
[ CAS No. ]:
1196994-11-2
[ Name ]:
ST-1006
Biological Activity
[Description]:
ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].
[Related Catalog]:
[Target]
H4 receptor:7.94 (pKi)
[In Vitro]
ST-1006 (10 μM) 是一种有效的嗜碱性粒细胞迁移诱导剂,可诱导嗜碱性粒细胞迁移[2]。 ST-1006 (0-100 μM) 抑制 FceRI 介导的嗜碱性粒细胞激活并降低 FceRI 激活的嗜碱性粒细胞的 CD63 和 CD203c 表达水平[2]。
[In Vivo]
ST-1006 (1-100 mg/kg;s.c.;雄性 CD-1 小鼠) 具有抗炎作用和止痒作用[1]。 Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1] Dosage: 1-100 mg/kg Administration: Subcutaneous injection Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C16H20Cl2N6
[ Molecular Weight ]:
367.28