Z-LVG-CHN2

Names

[ CAS No. ]:
119670-30-3

[ Name ]:
Z-LVG-CHN2

[Synonym ]:
Z-LEU-VAL-GLY-DIAZOMETHYLKETONE

Biological Activity

[Description]:

Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease[3].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HSV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

EC50: 190 nM (SAR-COV-2)[3]

[In Vitro]

Z-LVG-CHN2 (0-10 μM; pre-treated for 16 h) inhibits antiviral activities in a discernable dose-dependent manner in Vero E6 cells by designed to capture multicycle replication, exhibiting an EC50 value of 0.19 μM[1]/ Cell Viability Assay[3] Cell Line: Vero E6 cells Concentration: 0.001 μM, 0.003 μM, 0.1 μM, 0.3 μM, 1 μM, 2.5 μM Incubation Time: Pre-treated for 16 h and then cultured for 24 hours Result: Inhibited SARS-COV-2 virus replication in a dose-dependent manner.

[References]

[1]. R L Mellgren, et al. Inhibition of growth of human TE2 and C-33A cells by the cell-permeant calpain inhibitor benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone. Exp Cell Res. 1994 Nov;215(1):164-71.

[2]. L Björck, et al. Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus. J Virol

[3]. Laura Riva, et al.A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. bioRxiv. 2020 Apr 17;2020.04.16.044016.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₁N₅O₅

[ Molecular Weight ]:
445.51

[ Storage condition ]:
−20°C

Safety Information

[ Hazard Codes ]:
Xi

[ WGK Germany ]:
3

Related Compounds

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