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VA-K-14 hydrochloride

Names

[ CAS No. ]:
1171341-19-7

[ Name ]:
VA-K-14 hydrochloride

[Synonym ]:
MFCD10180795
2-Thiazolamine, N-methyl-4-(2-phenyl-1H-indol-3-yl)-
N-Methyl-4-(2-phenyl-1H-indol-3-yl)-1,3-thiazol-2-amine

Biological Activity

[Description]:

VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM)[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> TSH Receptor

[References]

[1]. Latif R, et al. TSH Receptor Signaling Abrogation by a Novel Small Molecule. Front Endocrinol (Lausanne). 2016;7:130. Published 2016 Sep 27.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
510.1±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H16ClN3S

[ Molecular Weight ]:
305.397

[ Flash Point ]:
262.3±30.7 °C

[ Exact Mass ]:
305.098663

[ LogP ]:
4.33

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.732

Related Compounds