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(Tyr0)-Neurokinin A

Names

[ CAS No. ]:
116868-93-0

[ Name ]:
(Tyr0)-Neurokinin A

[Synonym ]:
2-Thia-6,9,12,15,18,21-hexaazapentacosa-6,9,12,15,18,21-hexaen-25-oic acid, 23-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino]-1-hydroxy-3-(1H-imidazol-5-yl)propylidene]amino]-1-hydroxyhexylidene]amino]-1,3-dihydroxybutylidene]amino]-7,10,13,16,19,22-hexahydroxy-5-(hydroxyiminomethyl)-20-(hydroxymethyl)-14-(1-methylethyl)-8-(2-methylpropyl)-17-(phenylmethyl)-, (5S,8S,14S,17S,20S,23S)-
(5S,8S,14S,17S,20S,23S)-23-{[(2S,3R)-2-{[(2S)-6-Amino-2-{[(2S)-2-{[(2S)-2-amino-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxy-3-(1H-imidazol-5-yl)propylidene]amino}-1-hydroxyhexylidene]amino}-1,3-dihydroxybutylidene]amino}-17-benzyl-7,10,13,16,19,22-hexahydroxy-5-[hydroxy(imino)methyl]-20-(hydroxymethyl)-8-isobutyl-14-isopropyl-2-thia-6,9,12,15,18,21-hexaazapentacosa-6,9,12,15,18,21-hexaen-25-oic acid
YHKTDSFVGLM-NH2

Biological Activity

[Description]:

Tyr0-Neurokinin A is a neuropeptide belongs to tachykinin peptide family. Tyr0-Neurokinin A is an agonist of Tacr2. Tyr0-Neurokinin A can be used in the research of insulin resistance, obesity, diabetes[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[Target]

Tachykinin Receptor 2 (Tacr2)[2]


[References]

[1]. Gao X, et al. The study of the conformation and interaction of two tachykinin peptides in membrane mimicking systems by NMR spectroscopy and pulsed field gradient diffusion. Biopolymers. 1999 Oct 15;50(5):555-68.  

[2]. Gerhart-Hines Zachary, et al. Peptide agonists of Tacr2 for treatment of insulin resistance, diabetes and/or obesity. Patent. WO2021073742.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1399.4±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C59H89N15O16S

[ Molecular Weight ]:
1296.494

[ Flash Point ]:
800.1±37.1 °C

[ Exact Mass ]:
1295.633301

[ LogP ]:
8.61

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.650

Related Compounds