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niloticin

Names

[ CAS No. ]:
115404-57-4

[ Name ]:
niloticin

[Synonym ]:
niloticin
(13α,14β,17α,20S,23R,24S)-23-Hydroxy-24,25-epoxylanost-7-en-3-one
Lanost-7-en-3-one, 24,25-epoxy-23-hydroxy-, (13α,14β,17α,20S,23R,24S)-

Biological Activity

[Description]:

Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[References]

[1]. Xu H, et al. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways. Biomed Pharmacother. 2022 May;149:112902.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
538.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H48O3

[ Molecular Weight ]:
456.70

[ Flash Point ]:
165.4±22.2 °C

[ Exact Mass ]:
456.360352

[ PSA ]:
49.83000

[ LogP ]:
7.24

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.543

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds