Ibuprofen Acyl-b-D-glucuronide

Names

[ Name ]:
Ibuprofen Acyl-b-D-glucuronide

[Synonym ]:
ibuprofen acyl glucuronide
Ibuprofen Acyl--D-glucuronide
1-[a-Methyl-4-(2-methylpropyl)benzeneacetate]-D-Glucopyranuronic Acid
Ibuprofen Acyl-Beta-D-glucuronide
Ibuprofen glucuronide

Chemical & Physical Properties

[ Density]:
1.34g/cm3

[ Boiling Point ]:
567.3ºC at 760 mmHg

[ Melting Point ]:
26-28ºC

[ Molecular Formula ]:
C₁₉H₂₆O₈

[ Molecular Weight ]:
382.40500

[ Flash Point ]:
198.3ºC

[ Exact Mass ]:
382.16300

[ PSA ]:
133.52000

[ LogP ]:
0.42400

[ Vapour Pressure ]:
1.05E-13mmHg at 25°C

[ Index of Refraction ]:
1.581

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

[ Stability ]:
Hygroscopic, Not stable in aqueous solutions.

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Direct determination of ibuprofen and ibuprofen acyl glucuronide in plasma by high-performance liquid chromatography using solid-phase extraction.

J. Chromatogr. A. 614(1) , 109-16, (1993)

A method for the simultaneous determination of ibuprofen and its labile, reactive metabolite, ibuprofen acyl glucuronide, in plasma is described. Reversed-phase high-performance liquid chromatography ...

Disposition and reactivity of ibuprofen and ibufenac acyl glucuronides in vivo in the rhesus monkey and in vitro with human serum albumin.

Drug Metab. Dispos. 23(5) , 566-72, (1995)

The disposition of ibuprofen and ibufenac, an analog of ibuprofen with a history of severe adverse reactions, was investigated in Rhesus monkeys after oral administration. Plasma concentrations of the...

Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4.

J. Pharmacol. Exp. Ther. 356 , 366-74, (2016)

Combined administration of methotrexate (MTX) and nonsteroidal anti-inflammatory drugs (NSAIDs) can result in a decreased systemic clearance of MTX. To date, inhibition of renal uptake via organic ani...