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Bromo-PEG3-C2-phosphonic acid

Names

[ CAS No. ]:
1148026-99-6

[ Name ]:
Bromo-PEG3-C2-phosphonic acid

[Synonym ]:
MFCD11982881
Phosphonic acid, [2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethyl]-
(2-{2-[2-(2-Bromoethoxy)ethoxy]ethoxy}ethyl)phosphonic acid

Biological Activity

[Description]:

Bromo-PEG3-C2-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
458.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H18BrO6P

[ Molecular Weight ]:
321.103

[ Flash Point ]:
230.9±31.5 °C

[ Exact Mass ]:
320.002441

[ LogP ]:
-1.75

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.497

Related Compounds