Letrozole-d4
Names
[ CAS No. ]:
1133712-96-5
[ Name ]:
Letrozole-d4
Biological Activity
[Description]:
Letrozole-d4 (CGS 20267-d4) is the deuterium labeled Letrozole. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].
[Related Catalog]:
[In Vitro]
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[References]
Chemical & Physical Properties
[ Melting Point ]:
178-181 °C
[ Molecular Formula ]:
C17H7D4N5
[ Molecular Weight ]:
289.32700
[ Exact Mass ]:
289.12700
[ PSA ]:
78.29000
[ LogP ]:
2.65916
Safety Information
[ Hazard Codes ]:
Xi