h-8 dihydrochloride

Names

[ CAS No. ]:
113276-94-1

[ Name ]:
h-8 dihydrochloride

[Synonym ]:
H-8 dihydrochloride
MFCD00036962

Biological Activity

[Description]:

H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA

Signaling Pathways >> Stem Cell/Wnt >> PKA

[References]

[1]. Niisato N, et al. Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms. Life Sci. 1999;65(10):PL109-14.

Chemical & Physical Properties

[ Boiling Point ]:
473.9ºC at 760 mmHg

[ Melting Point ]:
221-222℃ (methanol water )

[ Molecular Formula ]:
C₁₂H₁₇Cl₂N₃O₂S

[ Molecular Weight ]:
338.25300

[ Flash Point ]:
240.4ºC

[ Exact Mass ]:
337.04200

[ PSA ]:
79.47000

[ LogP ]:
4.19910

[ Vapour Pressure ]:
3.79E-09mmHg at 25°C

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 25 mg/mL, clear, colorless

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

Biochemistry 23 , 5036-5041, (1984)

Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the...

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

Mol. Cell. Biol. 9 , 2424, (1989)

We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interle...