SMPT

Names

[ Name ]:
SMPT

[Synonym ]:
1-({4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoyl}oxy)pyrrolidine-2,5-dione
SMPT
2,5-Pyrrolidinedione,1-((4-(1-(2-pyridinyldithio)ethyl)benzoyl)oxy)

Biological Activity

[Description]:

SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
547ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₁₆N₂O₄S₂

[ Molecular Weight ]:
388.46100

[ Flash Point ]:
284.6ºC

[ Exact Mass ]:
388.05500

[ PSA ]:
127.17000

[ LogP ]:
3.74180

[ Vapour Pressure ]:
5.11E-12mmHg at 25°C

[ Index of Refraction ]:
1.675

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.