CM 572

A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors; induces dose-dependent cell death in SK-N-SH cells with EC50 of 7.6 uM, also demonstrates selective cytotoxic activity against PANC-1 pancreatic and MCF-7 breast cancer cell lines, with no significant effect on normal cells.

References 1. Nicholson H, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. 2. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. View Related Products by Target Sigma Receptor